Ongoing Research Projects

Our team has a number of ongoing research projects aimed at gaining insights into TFE RCC biology and treatment options:

1. Genomic characterization of TFE RCC via whole genome sequencing, DNA methylation profiling, and RNA transcriptome analyses (AREN14B4-Q) – PI Dr. James Geller
2. PDX/Cell line establishment of TFE RCC
   1. Create new models – TRRI team
   2. Use models for drug testing and biological insights – PI Dr. Alex Bondoc
   1. Current experiments aim to understand the resistance mechanisms of TFE RCC to anti-angiogenic therapy
3. Drug screening – Accumulating cell lines from TFE RCC for high-throughput screening – TRRI team